RT Journal Article T1 Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study. A1 Del Rosal, Teresa A1 Méndez-Echevarría, Ana A1 Garcia-Vera, Cesar A1 Escosa-Garcia, Luis A1 Agud, Martin A1 Chaves, Fernando A1 Román, Federico A1 Gutierrez-Fernandez, José A1 Ruiz de Gopegui, Enrique A1 Ruiz-Carrascoso, Guillermo A1 Ruiz-Gallego, Maria Del Carmen A1 Bernet, Albert A1 Quevedo, Sara Maria A1 Fernández-Verdugo, Ana Maria A1 Díez-Sebastian, Jesús A1 Calvo, Cristina A1 COSACO Study Group, K1 MRSA K1 S. aureus K1 child K1 colonization AB To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children. Cross-sectional study of patients A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9-35.1) and 1.44% (95% CI 0.9-2), respectively. Thirty-three percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age ≥5 years (OR 1.10, 95% CI 1.07-1.12), male sex (OR 1.43, 95% CI 1.17-1.76), urban setting (OR 1.46, 95% CI 1.08-1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093-1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57-8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings. SN 1178-6973 YR 2020 FD 2020-12-23 LK http://hdl.handle.net/10668/16880 UL http://hdl.handle.net/10668/16880 LA en DS RISalud RD Apr 5, 2025