%0 Journal Article
%A Remuzgo-Martinez, Sara
%A Atienza-Mateo, Belen
%A Ocejo-Vinyals, J Gonzalo
%A Pulito-Cueto, Veronica
%A Prieto-Peña, Diana
%A Genre, Fernanda
%A Marquez, Ana
%A Llorca, Javier
%A Mora Cuesta, Victor M
%A Fernandez, David Iturbe
%A Riesco, Laura
%A Ortego-Centeno, Norberto
%A Gomez, Nair Perez
%A Mera, Antonio
%A Martinez-Barrio, Julia
%A Lopez-Longo, Francisco Javier
%A Lera-Gomez, Leticia
%A Moriano, Clara
%A Diez, Elvira
%A Tomero, Eva
%A Calvo-Alen, Jaime
%A Romero-Bueno, Fredeswinda
%A Sanchez-Pernaute, Olga
%A Nuño, Laura
%A Bonilla, Gema
%A Grafia, Ignacio
%A Prieto-Gonzalez, Sergio
%A Narvaez, Javier
%A Trallero-Araguas, Ernesto
%A Selva-O'Callaghan, Albert
%A Gualillo, Oreste
%A Martin, Javier
%A Cavagna, Lorenzo
%A Castañeda, Santos
%A Cifrian, Jose M
%A Renzoni, Elisabetta A
%A Lopez-Mejias, Raquel
%A Gonzalez-Gay, Miguel A
%T HLA association with the susceptibility to anti-synthetase syndrome.
%D 2020
%U http://hdl.handle.net/10668/16769
%X To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P=1.56E-09, odds ratio-OR [95% confidence interval-CI]=2.54 [1.84-3.50] and 21.4% versus 5.5%, P=18.95E-18, OR [95% CI]=4.73 [3.18-7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P=0.0003, OR [95% CI]=0.48 [0.31-0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P=0.001, OR [95% CI]=2.54 [1.39-4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Our results support the association of the HLA complex with the susceptibility to ASSD.
%K Anti-Jo-1 antibodies
%K Anti-synthetase syndrome
%K HLA
%K HLA-B*08:01
%K HLA-DRB1*03:01
%K HLA-DRB1*07:01
%~