TY - JOUR AU - Rodríguez-Hernández, María A. AU - de la Cruz-Ojeda, P. AU - López-Grueso, Mª José AU - Navarro-Villarán, Elena AU - Requejo-Aguilar, Raquel AU - Castejón-Vega, Beatriz AU - Negrete, María AU - Gallego, Paloma AU - Vega-Ochoa, Álvaro AU - Victor, Victor M. AU - Cordero, Mario D. AU - Del Campo, José A. AU - Bárcena, J. Antonio AU - Padilla, C. Alicia AU - Muntané, Jordi PY - 2020 DO - 10.1016/j.redox.2020.101510 UR - http://hdl.handle.net/10668/3608 T2 - Redox Biology AB - Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis, cellular stress, and sustained angiogenesis, invasiveness and metastatic potential. Cancer cells adequately adapt cell metabolism and... LA - en PB - Elsevier B.V. KW - Autophagy KW - Cell death KW - Endoplasmic reticulum stress KW - mTOR KW - Redox status KW - PGC-1α KW - Autofagia KW - Muerte celular KW - Estrés del retículo endoplásmico KW - Serina-treonina quinasas TOR KW - Oxidación-reducción KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Autophagy KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Proto-Oncogene Proteins c-akt KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment KW - Medical Subject Headings::Diseases::Neoplasms KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases::Phosphatidylinositol 3-Kinase TI - Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer TY - review article ER -