TY - JOUR AU - Martin-Broto, J AU - Redondo, A AU - Valverde, C AU - Vaz, M A AU - Mora, J AU - Garcia Del Muro, X AU - Gutierrez, A AU - Tous, C AU - Carnero, A AU - Marcilla, D AU - Carranza, A AU - Sancho, P AU - Martinez-Trufero, J AU - Diaz-Beveridge, R AU - Cruz, J AU - Encinas, V AU - Taron, M AU - Moura, D S AU - Luna, P AU - Hindi, N AU - Lopez-Pousa, A PY - 2017 DO - 10.1093/annonc/mdx536 UR - http://hdl.handle.net/10668/11695 T2 - Annals of oncology : official journal of the European Society for Medical Oncology AB - Patients with relapsed unresectable osteosarcoma represents an unmet need, so active and safe systemic treatments are required. Fas cell surface death receptor and mammalian target of rapamycin pathways are implicated in progressing osteosarcoma, and... LA - en KW - RRM1 KW - gemcitabine KW - osteosarcoma KW - phase II KW - second-line KW - sirolimus KW - Adolescent KW - Adult KW - Antineoplastic Combined Chemotherapy Protocols KW - Bone Neoplasms KW - Child KW - Child, Preschool KW - Deoxycytidine KW - Disease Progression KW - Disease-Free Survival KW - Female KW - Humans KW - Male KW - Middle Aged KW - Osteosarcoma KW - Recurrence KW - Sirolimus KW - Young Adult KW - Gemcitabine TI - Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS). TY - research article VL - 28 ER -