RT Journal Article
T1 Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study.
A1 Alonso, Silvia Patricia
A1 Valdes, Sergio
A1 Maldonado-Araque, Cristina
A1 Lago, Ana
A1 Ocon, Pilar
A1 Calle, Alfonso
A1 Castaño, Luis
A1 Delgado, Elias
A1 Menendez, Edelmiro
A1 Franch-Nadal, Josep
A1 Gaztambide, Sonia
A1 Girbes, Juan
A1 Chaves, Felipe
A1 Garcia-Serrano, Sara
A1 Garcia-Escobar, Eva
A1 Fernandez-Garcia, Jose Carlos
A1 Olveira, Gabriel
A1 Colomo, Natalia
A1 Rojo-Martinez, Gemma
K1 Risk Factors
K1 Spain
K1 Thyroid Function Tests
K1 Thyroid Hormone Resistance Syndrome
K1 Young Adult
AB It has been proposed that a mild form of acquired resistance to thyroid hormone may occur in the general population. Its clinical significance remains largely unknown. The objective of the study was to explore whether a newly described thyroid hormone resistance index is associated with the risk of mortality in a sample of community-dwelling euthyroid subjects representative of the adult population of Spain. Longitudinal observational study including 3750 individuals, free of thyroid disease, TPO antibodies-negative ( We used the Thyroid Feedback Quantile-based Index (TFQI) as a marker of resistance to thyroid hormone. The study population was grouped into categories according to their TFQI values at baseline. Fatal events were ascertained from the national death registry (end of follow-up December 2016). A total of 231 deaths were recorded during an average follow-up of 7.3 years. Compared with the category with the highest sensitivity to free thyroxine (TFQI ≤ p5) (reference), the relative risk of mortality in the categories with TFQI > p5 and ≤p25; >p25 and ≤p50; >p50 and ≤p75; >p75 and ≤p95 and >p95 were 1.01, (0.47-2.19), 1.42 (0.68-2.97), 1.54 (0.74-3.22), 1.47 (0.70-3.11) and 2.61 (1.16-5.89), respectively (P for trend 0.003). The association remained significant after multivariate adjustment of the data (P for trend 0.017). A thyroid hormone resistance index focused on deviations of the average pituitary response to thyroid hormones may be associated with all-cause mortality independently of other conventional risk factors and comorbidities.
PB Oxford University Press
YR 2021
FD 2021-11-04
LK http://hdl.handle.net/10668/20443
UL http://hdl.handle.net/10668/20443
LA en
NO Alonso SP, Valdés S, Maldonado-Araque C, Lago A, Ocon P, Calle A, et al.  Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study. Eur J Endocrinol. 2021 Dec 1;186(1):95-103
NO CIBERDEM (Ministerio de Economía, Industria y Competitividad-ISCIII),Instituto de Salud Carlos III (PI11-02755, PI20/01322), Consejería de Saludy familias (PI-0144-2018), European Regional Development Fund (ERDF)‘A way to build Europe’. GRM belongs to the regional Nicolás Monardesresearch program of the Consejería de Salud (C-0060-2012 and RC0006-2016; Junta de Andalucía, Spain). CMA is recipient of a ‘Rio Hortega’ research contract (CM19/00186, Instituto de Salud Carlos III).
DS RISalud
RD Apr 7, 2025