RT Journal Article
T1 Trajectories of alcohol consumption during life and the risk of developing breast cancer.
A1 Donat-Vargas, Carolina
A1 Guerrero-Zotano, Ángel
A1 Casas, Ana
A1 Baena-Cañada, José Manuel
A1 Lope, Virginia
A1 Antolín, Silvia
A1 Garcia-Saénz, José Ángel
A1 Bermejo, Begoña
A1 Muñoz, Montserrat
A1 Ramos, Manuel
A1 de Juan, Ana
A1 Jara Sánchez, Carlos
A1 Sánchez-Rovira, Pedro
A1 Antón, Antonio
A1 Brunet, Joan
A1 Gavilá, Joaquín
A1 Salvador, Javier
A1 Arriola Arellano, Esperanza
A1 Bezares, Susana
A1 Fernández de Larrea-Baz, Nerea
A1 Pérez-Gómez, Beatriz
A1 Martín, Miguel
A1 Pollán, Marina
K1 Alcohol
K1 Breast cancer
K1 Adolescence
K1 Trajectories
K1 Risk
AB Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
PB Nature
SN 1532-1827
YR 2021
FD 2021-09-06
LK https://hdl.handle.net/10668/25305
UL https://hdl.handle.net/10668/25305
LA en
NO Donat-Vargas C, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Lope V, Antolín S, et al. Trajectories of alcohol consumption during life and the risk of developing breast cancer. Br J Cancer. 2021;125(8):1168-1176.
NO This study was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016) (Marina Pollán), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology) (Miguel Martín), Scholarship ‘Contrato de atracción de talento’ from Community of Madrid (Carolina Donat-Vargas), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) (Miguel Martín) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer) (Miguel Martín, Marina Pollán).
DS RISalud
RD Aug 6, 2025