RT Journal Article
T1 Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia.
A1 Holubiec, Mariana I
A1 Romero, Juan I
A1 Blanco, Eduardo
A1 Tornatore, Tamara Logica
A1 Suarez, Juan
A1 Rodriguez-de-Fonseca, Fernando
A1 Galeano, Pablo
A1 Capani, Francisco
K1 CB1
K1 DAGLα
K1 Dorsal striatum
K1 NAPE-PLD
K1 PPARα
K1 Perinatal asphyxia
AB Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.
PB Elsevier
YR 2017
FD 2017-06-01
LK http://hdl.handle.net/10668/11271
UL http://hdl.handle.net/10668/11271
LA en
NO Holubiec MI, Romero JI, Blanco E, Tornatore TL, Suarez J, Rodríguez de Fonseca F, et al. Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia. Neurosci Lett. 2017 Jul 13;653:269-275
DS RISalud
RD Apr 10, 2025