RT Journal Article
T1 Role of total tumour load of sentinel lymph node on survival in early breast cancer patients.
A1 Peg, Vicente
A1 Sansano, Irene
A1 Vieites, Begoña
A1 Bernet, Laia
A1 Cano, Rafael
A1 Córdoba, Alicia
A1 Sancho, Magdalena
A1 Martín, María Dolores
A1 Vilardell, Felip
A1 Cazorla, Alicia
A1 Espinosa-Bravo, Martín
A1 Pérez-García, José Manuel
A1 Cortés, Javier
A1 Rubio, Isabel T
A1 Ramón Y Cajal, Santiago
K1 Breast cancer
K1 Prognosis
K1 Sentinel lymph node
K1 Total tumour load
AB Axillary staging (pN) is considered one of the most important prognostic factors in breast cancer patients. However, the Z0011 study data drastically reduced the number of surgical axillary dissections in a selected group of patients, limiting the prognostic information relating to axillary involvement to the sentinel lymph node (SLN). It is known that there is a relationship between SLN total tumour load (TTL) and axillary involvement. The objective of this study is to analyse the relationship between the TTL and outcomes in patients with early stage breast cancer. clinicopathological and follow-up data were collected from 950 patients with breast cancer between 2009 and 2010 on whom SLN analysis was conducted by molecular methods (One Step Nucleic Acid Amplification, Sysmex, Kobe, Japan). TTL (defined as the total number of CK19 mRNA copies in all positive SLN) correlates with disease free survival (HR, 1.08; p = 0.000004), with local recurrence disease free survival (HR = 1.07; p = 0.0014) and overall survival (HR: 1.08, p = 0.0032), clearly defining a low-risk group (TTL 2.5 × 104 CK 19 mRNA copies/μL). SLN TTL permits the differentiation between two patient groups in terms of DFS and OS, independently of axillary staging (pN), age and tumour characteristics (size, grade, lymphovascular invasion). This new data confirms the clinical value of low axillary involvement and could partially replace the information that staging of the entire axilla provides in patients on whom no axillary lymph node dissection is performed.
YR 2017
FD 2017-02-28
LK http://hdl.handle.net/10668/10923
UL http://hdl.handle.net/10668/10923
LA en
DS RISalud
RD Apr 6, 2025