RT Journal Article
T1 Coronary Heart Disease, Peripheral Arterial Disease, and Stroke in Familial Hypercholesterolaemia: Insights From the SAFEHEART Registry (Spanish Familial Hypercholesterolaemia Cohort Study).
A1 Pérez de Isla, Leopoldo
A1 Alonso, Rodrigo
A1 Mata, Nelva
A1 Saltijeral, Adriana
A1 Muñiz, Ovidio
A1 Rubio-Marin, Patricia
A1 Diaz-Diaz, José L
A1 Fuentes, Francisco
A1 de Andrés, Raimundo
A1 Zambón, Daniel
A1 Galiana, Jesús
A1 Piedecausa, Mar
A1 Aguado, Rocio
A1 Mosquera, Daniel
A1 Vidal, José I
A1 Ruiz, Enrique
A1 Manjón, Laura
A1 Mauri, Marta
A1 Padró, Teresa
A1 Miramontes, José P
A1 Mata, Pedro
A1 SAFEHEART Investigators, 
K1 coronary disease
K1 genetics
K1 hypercholesterolemia
K1 peripheral vascular diseases
K1 stroke
AB Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)-related monogenic disorder, and it is associated with ischemic heart disease. There is limited information whether FH increases the risk of peripheral arterial and cerebrovascular disease. Our aim was to analyze ASCVD prevalence and characteristics in different arterial territories in a large FH population, to compare them with an unaffected control population and to determine which factors are associated to ASCVD. SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) is an ongoing registry of molecularly defined patients with heterozygous FH in Spain. ASCVD in the different arterial territories was analyzed, as well as individual characteristics, genetic variables, and lipid-lowering therapies. The study recruited 4132 subjects (3745 ≥18 years); 2,752 of those enrolled were molecularly diagnosed FH cases. Median age was 44.0 years (45.9% men) and 40 years (46.6% men) in FH patients and unaffected relatives (P50 mg/dL were independently associated with ASCVD. The prevalence of ASCVD is higher, and the involvement of the arterial territories is different in FH patients when compared with their unaffected relatives. Age, male sex, increased body mass index, hypertension, type 2 diabetes mellitus, smoking habit, and lipoprotein(a) >50 mg/dL were independently associated to ASCVD. URL: https://www.clinicaltrials.gov. Unique identifier: NCT02693548.
YR 2016
FD 2016-07-21
LK http://hdl.handle.net/10668/10296
UL http://hdl.handle.net/10668/10296
LA en
DS RISalud
RD Apr 5, 2025