TY - JOUR AU - Collazos, Julio AU - Domingo, Pere AU - Fernandez-Araujo, Nerio AU - Asensi-Diaz, Elia AU - Vilchez-Rueda, Helem AU - Lalueza, Antonio AU - Roy-Vallejo, Emilia AU - Blanes, Rosa AU - Raya-Cruz, Manuel AU - Sanz-Canovas, Jaime AU - Artero, Arturo AU - Ramos-Rincon, Jose-Manuel AU - DueƱas-Gutierrez, Carlos AU - Lamas-Ferreiro, Jose Luis AU - Asensi, Victor PY - 2022 DO - 10.1371/journal.pone.0262777 UR - http://hdl.handle.net/10668/20415 T2 - PloS one AB - Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study has analyzed its efficacy in the clinical setting. This multicenter, retrospective study included 165 adult patients receiving VPA at the time of... LA - en PB - Public Library of Science KW - Severity of Illness Index KW - Spain KW - Treatment Outcome KW - Valproic Acid KW - COVID-19 Drug Treatment KW - Aged KW - Blood Cell Count KW - COVID-19 KW - Female KW - Hospitalization KW - Humans KW - Inflammation KW - Lung KW - Male KW - Middle Aged KW - Retrospective Studies KW - SARS-CoV-2 TI - Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19. TY - research article VL - 17 ER -