RT Journal Article
T1 Enrichment of Food With Tannin Extracts Promotes Healthy Changes in the Human Gut Microbiota
A1 Molino, Silvia
A1 Lerma-Aguilera, Alberto
A1 Jiménez-Hernández, Nuria
A1 Gosalbes, María José
A1 Rufián-Henares, José Ángel
A1 Francino, M Pilar
K1 Chestnut
K1 Gut microbiota
K1 In vitro digestion-fermentation
K1 Quebracho
K1 Short chain fatty acids
K1 Tannins
K1 Tara
K1 Aesculus
K1 Microbioma gastrointestinal
K1 Quebracho
K1 Ácidos grasos volátiles
K1 Taninos
AB Food and food bioactive components are major drivers of modulation of the human gut microbiota. Tannin extracts consist of a mix of bioactive compounds, which are already exploited in the food industry for their chemical and sensorial properties. The aim of our study was to explore the viability of associations between tannin wood extracts of different origin and food as gut microbiota modulators. 16S rRNA amplicon next-generation sequencing (NGS) was used to test the effects on the gut microbiota of tannin extracts from quebracho, chestnut, and tara associated with commercial food products with different composition in macronutrients. The different tannin-enriched and non-enriched foods were submitted to in vitro digestion and fermentation by the gut microbiota of healthy subjects. The profile of the short chain fatty acids (SCFAs) produced by the microbiota was also investigated. The presence of tannin extracts in food promoted an increase of the relative abundance of the genus Akkermansia, recognized as a marker of a healthy gut, and of various members of the Lachnospiraceae and Ruminococcaceae families, involved in SCFA production. The enrichment of foods with tannin extracts had a booster effect on the production of SCFAs, without altering the profile given by the foods alone. These preliminary results suggest a positive modulation of the gut microbiota with potential benefits for human health through the enrichment of foods with tannin extracts.
PB Frontiers
YR 2021
FD 2021-03-16
LK http://hdl.handle.net/10668/3511
UL http://hdl.handle.net/10668/3511
LA en
NO Molino S, Lerma-Aguilera A, Jiménez-Hernández N, Gosalbés MJ, Rufián-Henares JA, Francino M. Enrichment of Food With Tannin Extracts Promotes Healthy Changes in the Human Gut Microbiota. Frontiers in Microbiology. 2021 Mar 16;12:625782
DS RISalud
RD Apr 11, 2025