RT Journal Article
T1 Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study.
A1 Duell, Eric J
A1 Lujan-Barroso, Leila
A1 Sala, Núria
A1 Deitz McElyea, Samantha
A1 Overvad, Kim
A1 Tjonneland, Anne
A1 Olsen, Anja
A1 Weiderpass, Elisabete
A1 Busund, Lill-Tove
A1 Moi, Line
A1 Muller, David
A1 Vineis, Paolo
A1 Aune, Dagfinn
A1 Matullo, Giuseppe
A1 Naccarati, Alessio
A1 Panico, Salvatore
A1 Tagliabue, Giovanna
A1 Tumino, Rosario
A1 Palli, Domenico
A1 Kaaks, Rudolf
A1 Katzke, Verena A
A1 Boeing, Heiner
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Kotanidou, Anastasia
A1 Travis, Ruth C
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Ramon Quiros, Jose
A1 Rodríguez-Barranco, Miguel
A1 Dorronsoro, Miren
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Severi, Gianluca
A1 Boutron-Ruault, Marie-Christine
A1 Rebours, Vinciane
A1 Brennan, Paul
A1 Gunter, Marc
A1 Scelo, Ghislaine
A1 Cote, Greg
A1 Sherman, Stuart
A1 Korc, Murray
K1 biomarkers
K1 cohort studies
K1 microRNAs
K1 pancreatic cancer
AB Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection. MiR levels in prediagnostic plasma samples were determined by quantitative RT-PCR. Logistic regression was used to model levels and PDAC risk, adjusting for covariates and to estimate area under the receiver operating characteristic curves (AUC). Plasma miR-10b, -21-5p, -30c and -106b levels were significantly higher in cases diagnosed within 2 years of blood collection compared to matched controls (all p-values
YR 2017
FD 2017-06-12
LK http://hdl.handle.net/10668/11237
UL http://hdl.handle.net/10668/11237
LA en
DS RISalud
RD Apr 10, 2025