RT Journal Article
T1 Single nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma.
A1 Garrigós, Carmen
A1 Espinosa, Marta
A1 Salinas, Ana
A1 Osman, Ignacio
A1 Medina, Rafael
A1 Taron, Miguel
A1 Molina-Pinelo, Sonia
A1 Duran, Ignacio
K1 advanced renal cell carcinoma
K1 angiogenesis genes
K1 biomarkers
K1 localized renal cell carcinoma
K1 single nucleotide polymorphisms
AB Despite major advances in the knowledge of the molecular basis of renal cell carcinoma, prognosis is still defined using clinical and pathological parameters. Moreover, no valid predictive biomarkers exist to help us selecting the best treatment for each patient. With these premises, we aimed to analyse the expression and to determine the prognostic and predictive value of 64 key single nucleotide polymorphisms in 18 genes related with angiogenesis or metabolism of antiangiogenics in two cohorts of patients with localized and advanced renal cell cancer treated at our institution. The presence of the selected single nucleotide polymorphisms was correlated with clinical features, disease free survival, overall survival and response rate. In patients with localized renal cell cancer, 5 of these polymorphisms in 3 genes involved in angiogenesis predicted for worse disease free survival (VEGFR2: rs10013228; PDGFRA: rs2228230) or shorter overall survival (VEGFR2: rs10013228; VEGFR3: rs6877011, rs307826) (p
YR 2017
FD 2017-11-20
LK https://hdl.handle.net/10668/25147
UL https://hdl.handle.net/10668/25147
LA en
DS RISalud
RD Apr 12, 2025