RT Journal Article
T1 Antiparasitic Activity of Bromotyrosine Alkaloids and New Analogues Isolated from the Fijian Marine Sponge Aplysinella rhax.
A1 Oluwabusola, Emmanuel T
A1 Tabudravu, Jioji N
A1 Al Maqbali, Khalid S
A1 Annang, Frederick
A1 Pérez-Moreno, Guiomar
A1 Reyes, Fernando
A1 Jaspars, Marcel
K1 Chagas disease
K1 bromotyrosine
K1 malaria
K1 psammaplin
K1 sponge
AB Ten bromotyrosine alkaloids were isolated and characterised from the marine sponge Aplysinella rhax (de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P and two other analogues, psammaplin O and 3-bromo-2-hydroxy-5-(methoxycarbonyl)benzoic acid, which have not been previously reported from natural sources. HR-ESI-MS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC50 at 19±5 and 29±6 μM against Trypanzoma cruzi Tulahuen C4, and the lethal human malaria species Plasmodium falciparum clone 3D7, respectively, while psammaplins A and D exhibited low activity against both parasites. This is the first report of the antimalarial and antitrypanosomal activity of the psammaplin-type compounds. Additionally, the biosynthesis hypotheses of three natural products were proposed.
YR 2020
FD 2020-09-29
LK http://hdl.handle.net/10668/15974
UL http://hdl.handle.net/10668/15974
LA en
DS RISalud
RD Apr 9, 2025