TY - JOUR AU - Garcia-Calderon, Clara B AU - Bejarano-Garcia, Jose Antonio AU - Tinoco-Gago, Isabel AU - Castro, Maria Jose AU - Moreno-Gordillo, Paula AU - Piruat, Jose I AU - Caballero-Velazquez, Teresa AU - Perez-Simon, Jose A AU - Rosado, Ivan V PY - 2018 DO - 10.1038/s41418-018-0089-4 UR - http://hdl.handle.net/10668/12214 T2 - Cell death and differentiation AB - Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily... LA - en PB - Nature Publishing Group KW - Alcohol Dehydrogenase KW - Apoptosis KW - Chickens KW - Genomic Instability KW - Histones KW - Animals KW - Cell Line KW - DNA Damage KW - DNA Repair KW - Fanconi Anemia Complementation Group Proteins KW - Hematopoiesis KW - Hematopoietic Stem Cells KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Phosphorylation KW - Tetrahydrofolates KW - Thymidylate Synthase TI - Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells. TY - research article VL - 25 ER -