RT Journal Article
T1 Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study.
A1 Lopez-Medrano, F
A1 Silva, J T
A1 Fernandez-Ruiz, M
A1 Carver, P L
A1 van-Delden, C
A1 Merino, E
A1 Perez-Saez, M J
A1 Montero, M
A1 Coussement, J
A1 de-Abreu-Mazzolin, M
A1 Cervera, C
A1 Santos, L
A1 Sabe, N
A1 Scemla, A
A1 Cordero, E
A1 Cruzado-Vega, L
A1 Martin-Moreno, P L
A1 Len, O
A1 Rudas, E
A1 de Leon, A Ponce
A1 Arriola, M
A1 Lauzurica, R
A1 David, M
A1 Gonzalez-Rico, C
A1 Henriquez-Palop, F
A1 Fortun, J
A1 Nucci, M
A1 Manuel, O
A1 Paño-Pardo, J R
A1 Montejo, M
A1 Muñoz, P
A1 Sanchez-Sobrino, B
A1 Mazuecos, A
A1 Pascual, J
A1 Horcajada, J P
A1 Lecompte, T
A1 Lumbreras, C
A1 Moreno, A
A1 Carratala, J
A1 Blanes, M
A1 Hernandez, D
A1 Hernandez-Mendez, E A
A1 Fariñas, M C
A1 Perello-Carrascosa, M
A1 Morales, J M
A1 Andres, A
A1 Aguado, J M
K1 Clinical research/practice
K1 Epidemiology
K1 Fungal
K1 Infection and infectious agents
K1 Infectious disease
K1 Kidney transplantation/nephrology
AB Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 kidney transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control recipients were matched (1:1 ratio) by center and date of transplantation. Overall mortality among cases was 60.8%, and 25.0% of living recipients experienced graft loss. Pretransplant diagnosis of chronic pulmonary obstructive disease (COPD; odds ratio [OR]: 9.96; 95% confidence interval [CI]: 1.09-90.58; p = 0.041) and delayed graft function (OR: 3.40; 95% CI: 1.08-10.73; p = 0.037) were identified as independent risk factors for IPA among those variables already available in the immediate peritransplant period. The development of bloodstream infection (OR: 18.76; 95% CI: 1.04-339.37; p = 0.047) and acute graft rejection (OR: 40.73, 95% CI: 3.63-456.98; p = 0.003) within the 3 mo prior to the diagnosis of IPA acted as risk factors during the subsequent period. In conclusion, pretransplant COPD, impaired graft function and the occurrence of serious posttransplant infections may be useful to identify KT recipients at the highest risk of early IPA. Future studies should explore the potential benefit of antimold prophylaxis in this group.
PB Elsevier
YR 2016
FD 2016-01-13
LK http://hdl.handle.net/10668/9777
UL http://hdl.handle.net/10668/9777
LA en
NO López-Medrano F, Silva JT, Fernández-Ruiz M, Carver PL, van Delden C, Merino E, et al. Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study. Am J Transplant. 2016 Jul;16(7):2148-57
NO This research was supported by Plan Nacional de I+D+i and Instituto de Salud Carlos III (Proyecto Integrado de Excelencia [PIE] 13/00045), Subdireccion General de Redes y Centros de Investigacion Cooperativa, Spanish Ministry of  Economy and Competitiveness, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015) - co-financed by European Development Regional Fund (EDRF) “A way to achieve Europe.” The study was also co-financed with an unrestricted grant from Pfizer Pharmaceutical (REI-ANT-2013-01). Mario Fern andez-Ruiz holds a clinical research contract “Juan Rodes” (JR14/00036) from the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness.
DS RISalud
RD Apr 10, 2025