RT Journal Article
T1 A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.
A1 Fernandez-Jimenez, Nora
A1 Fore, Ruby
A1 Cilleros-Portet, Ariadna
A1 Lepeule, Johanna
A1 Perron, Patrice
A1 Kvist, Tuomas
A1 Tian, Fu-Ying
A1 Lesseur, Corina
A1 Binder, Alexandra M
A1 Lozano, Manuel
A1 Martorell-Marugan, Jordi
A1 Loke, Yuk J
A1 Bakulski, Kelly M
A1 Zhu, Yihui
A1 Forhan, Anne
A1 Sammallahti, Sara
A1 Everson, Todd M
A1 Chen, Jia
A1 Michels, Karin B
A1 Belmonte, Thalia
A1 Carmona-Saez, Pedro
A1 Halliday, Jane
A1 Daniele Fallin, M
A1 LaSalle, Janine M
A1 Tost, Jorg
A1 Czamara, Darina
A1 Fernandez, Mariana F
A1 Gomez-Martin, Antonio
A1 Craig, Jeffrey M
A1 Gonzalez-Alzaga, Beatriz
A1 Schmidt, Rebecca J
A1 Dou, John F
A1 Muggli, Evelyne
A1 Lacasaña, Marina
A1 Vrijheid, Martine
A1 Marsit, Carmen J
A1 Karagas, Margaret R
A1 Räikkönen, Katri
A1 Bouchard, Luigi
A1 Heude, Barbara
A1 Santa-Marina, Loreto
A1 Bustamante, Mariona
A1 Hivert, Marie-France
A1 Bilbao, Jose Ramon
AB Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings.
PB Nature Publishing Group
YR 2022
FD 2022-11-16
LK http://hdl.handle.net/10668/19636
UL http://hdl.handle.net/10668/19636
LA en
NO Fernandez-Jimenez N, Fore R, Cilleros-Portet A, Lepeule J, Perron P, Kvist T, et al. A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health. Commun Biol. 2022 Nov 30;5(1):1313
NO We would like to thank the Pregnancy and Childhood Epigenetics (PACE) consortium, as well as all the families that participated in these studies for their generous contribution. This work was partially funded by  GVSAN2018111086 from the Basque Department of Health and PI18/01142 from ISCIII - Spanish Ministry of Science and Innovation -cofounded by the ERDF “A way to make Europe” to JRB and LSM, espectively; and by the Joint Programming Initiative – A Healthy Diet for a Healthy Life (JPI HDHL) (NutriPROGRAM). ACP was supported by grant  GVSAN2019111085 from the Basque Department of Health to NFJ. Detailed acknowledgements and funding for each participating cohort are described in Supplementary Note 1.
DS RISalud
RD Apr 7, 2025