RT Journal Article
T1 Are there differences by sex in lung cancer characteristics at diagnosis? -a nationwide study
A1 Ruano-Ravina, Alberto
A1 Provencio, Mariano
A1 Calvo de Juan, Virginia
A1 Carcereny, Enric
A1 Estival, Anna
A1 Rodriguez-Abreu, Delvys
A1 Benitez, Gretel
A1 Lopez-Castro, Rafael
A1 Belver, Marta
A1 Guirado-Risueno, Maria
A1 Guirao-Rubio, Carlos
A1 Blasco, Ana
A1 Massuti, Bartomeu
A1 Ortega, Ana Laura
A1 Cobo, Manuel
A1 Mosquera-Martinez, Joaquin
A1 Aguado de la Rosa, Carlos
A1 Bosch-Barrera, Joaquim
A1 Sanchez-Gastaldo, Amparo
A1 del Barco Morillo, Edel
A1 Juan, Oscar
A1 Domine, Manuel
A1 Trigo, Jose Manuel
A1 Pereiro Corbacho, Diego
A1 Oramas, Juana
K1 Lung neoplasms
K1 symptoms
K1 sex
K1 smoking
K1 small cell lung cancer (SCLC)
K1 Gender
K1 Survival
K1 Stage
AB Background: Lung cancer causes approximately 25% of all cancer deaths. Despite its relevance, few studies have analyzed differences by sex at the time of diagnosis in terms of symptoms, stage, age or smoking status. We aim to assess if there are differences between men and women on these characteristics at diagnosis. Methods: We analyzed the Thoracic Tumour Registry (TTR), sponsored by the Spanish Lung Cancer Group using a case-series design. This is a nationwide registry of lung cancer cases which started recruitment in 2016. For each case included, clinicians fulfilled an electronic record registering demographic data, symptoms, exposure to lung cancer risk factors, and treatment received in detail. We compared men and women using descriptive statistics. Results: A total of 13,590 participants took part in this study, 25.6% women. Women were 4 years younger than men (64 vs. 69), and men had smoked more frequently. Adenocarcinoma was the most frequent histological type in both sexes. Stage IV at diagnosis was 50.8% in women compared to 43.6% in men. Weight loss/anorexia/asthenia was the most frequent symptom in both sexes and there were no differences in the number of symptoms at diagnosis. There were no relevant differences in the frequency or number of symptoms by sex when non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) were analyzed separately. Smoking status did not appear to cause different lung cancer presentation in men compared to women. Conclusions: There seems to be no differences in lung cancer characteristics by sex at the time at diagnosis on stage, specific symptoms or number of symptoms.
PB Ame publishing company
SN 2218-6751
YR 2021
FD 2021-10-01
LK https://hdl.handle.net/10668/26627
UL https://hdl.handle.net/10668/26627
LA en
DS RISalud
RD Apr 8, 2025