RT Journal Article
T1 [Chemotherapy-induced liver injury in children].
T2 Lesión hepática inducida por quimioterapia en niños.
A1 Urrutia-Maldonado, Emilia
A1 Abril-Molina, Ana
A1 Alés-Palmer, María
A1 Gómez-Luque, Jose María
A1 Muñoz de Rueda, Paloma
A1 Ocete-Hita, Esther
K1 Chemotherapy
K1 Children
K1 Drug-induced liver injury
K1 Hepatotoxicidad
K1 Hepatotoxicity
K1 Lesión hepática inducida por fármacos
K1 Niños
K1 Quimioterapia
AB Drug-induced liver injury due to chemotherapy is an important cause of morbidity in cancer patients, although its clinical manifestations are poorly understood. The objective of the present study was to determine the characteristics (forms of presentation, severity, and type of injury) of hepatotoxicity due to chemotherapy in children treated for cancer. A total of 22 oncological patients were included in the study, after ruling out other causes of increased transaminases (infectious, metabolic, autoimmune, or hereditary), according to the CIOMS causality scale, it is concluded that it was a possible, probable or definite episode of hepatic injury by drugs. All children had more than one episode of hepatotoxicity, and a total of 98 episodes are analysed. Methotrexate was the most commonly implicated drug. The histological pattern of predominant damage was hepatocellular. Only 2episodes were classified as serious. Idiosyncratic hepatotoxicity due to chemotherapy is frequent, with a tendency to relapse with re-exposure. Although it does not usually have important consequences, the high frequency makes it advisable to establish standardised safety algorithms with very strict monitoring of liver enzymes during high periods of risk in chemotherapy.
YR 2019
FD 2019-02-15
LK http://hdl.handle.net/10668/13583
UL http://hdl.handle.net/10668/13583
LA es
DS RISalud
RD Apr 9, 2025