TY  - JOUR
AU  - Perán, Macarena
AU  - López-Ruiz, Elena
AU  - García, María Ángel
AU  - Nadaraia-Hoke, Shorena
AU  - Brandt, Ralf
AU  - Marchal, Juan A
AU  - Kenyon, Julian
PY  - 2017
DO  - 10.1038/s41598-017-14571-x
UR  - http://hdl.handle.net/10668/11732
T2  - Scientific reports
AB  - Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and...
LA  - en
KW  - Animals
KW  - Apoptosis
KW  - Cell Proliferation
KW  - Chymotrypsinogen
KW  - Enzyme Precursors
KW  - Female
KW  - Humans
KW  - Mice
KW  - Mice, Nude
KW  - Neoplasm Metastasis
KW  - Ovarian Neoplasms
KW  - Pancreas
KW  - Pancreatic Neoplasms
KW  - Pilot Projects
KW  - Trypsinogen
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
TI  - A formulation of pancreatic pro-enzymes provides potent anti-tumour efficacy: a pilot study focused on pancreatic and ovarian cancer.
TY  - research article
VL  - 7
ER  -