RT Journal Article
T1 Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study.
A1 Fortuin-de Smidt, Melony C
A1 Sewe, Maquins Odhiambo
A1 Lassale, Camille
A1 Weiderpass, Elisabete
A1 Andersson, Jonas
A1 Huerta, Jose Maria
A1 Ekelund, Ulf
A1 Aleksandrova, Krasimira
A1 Tong, Tammy Yn
A1 Dahm, Christina C
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Steindorf, Karen
A1 Schulze, Matthias B
A1 Katzke, Verena
A1 Sacerdote, Carlotta
A1 Agnoli, Claudia
A1 Masala, Giovanna
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Boer, Jolanda Ma
A1 Onland-Moret, N Charlotte
A1 Wendel-Vos, Gc Wanda
A1 van der Schouw, Yvonne T
A1 Borch, Kristin Benjaminsen
A1 Agudo, Antonio
A1 Petrova, Dafina
A1 Chirlaque, María Dolores
A1 Conchi, Moreno Iribas
A1 Amiano, Pilar
A1 Melander, Olle
A1 Heath, Alicia K
A1 Aune, Dagfinn
A1 Forouhi, Nita G
A1 Langenberg, Claudia
A1 Brage, Soren
A1 Riboli, Elio
A1 Wareham, Nicholas J
A1 Danesh, John
A1 Butterworth, Adam S
A1 Wennberg, Patrik
K1 Case-cohort study
K1 Coronary heart disease
K1 Physical activity
K1 Population preventable fraction
K1 Risk factors
AB This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%). In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.
YR 2022
FD 2022-03-10
LK http://hdl.handle.net/10668/19773
UL http://hdl.handle.net/10668/19773
LA en
NO Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, et al. Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study. Eur J Prev Cardiol. 2022 Sep 7;29(12):1618-1629.
NO The coordination of EPIC is financially supported by International Agencyfor Research on Cancer (IARC) and also by the Department ofEpidemiology and Biostatistics, School of Public Health, ImperialCollege London which has additional infrastructure support providedby the NIHR Imperial Biomedical Research Centre (BRC). The establishment of the random sub-cohort was supported by the EU SixthFramework Programme (FP6) (grant LSHM_CT_2006_037197 to theInterAct project) and the Medical Research Council Epidemiology Unit(grants MC_UU_12015/1, MC_UU_12015/3, and MC_UU_12015/5).The national cohorts are supported by: Danish Cancer Society(Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, MutuelleGénérale de l’Education Nationale, Institut National de la Santé et dela Recherche Médicale (INSERM) (France); German Cancer Aid,German Cancer Research Center (DKFZ), German Institute of HumanNutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Educationand Research (BMBF) (Germany); Associazione Italiana per la Ricercasul Cancro-AIRC-Italy, Compagnia di SanPaolo and National ResearchCouncil (Italy); Dutch Ministry of Public Health, Welfare and Sports(VWS), Netherlands Cancer Registry (NKR), LK Research Funds,Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland),World Cancer Research Fund (WCRF), Statistics Netherlands (TheNetherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III(ISCIII), Regional Governments of Andalucía, Asturias, Basque Country,Murcia and Navarra, and the Catalan Institute of Oncology - ICO(Spain); Swedish Cancer Society, Swedish Research Council andCounty Councils of Skåne and Västerbotten (Sweden); TheEPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has receivedfunding from the Medical Research Council (MR/N003284/1,MC-UU_12015/1, and MC_UU_00006/1) and Cancer Research UK(C864/A14136) and EPIC-Oxford received funding from the MedialResearch Council (MR/M012190/1) and Cancer Research UK (C8221/A29017) (UK). Dr. Camille Lassale received the support of a fellowshipfrom ‘La Caixa’ Foundation (ID 100010434). The fellowship code is LCF/BQ/PR21/11840003. Claudia Langenberg, Nita Forouhi, Soren Brage,and Nick Wareham were supported by the UK Medical ResearchCouncil (MC_UU_00006/1, MC_UU_00006/3, and MC_UU_00006/4)and also received funding from NIHR Cambridge Biomedical ResearchCentre: nutrition, diet, and lifestyle research theme (IS-BRC-1215-20014).
DS RISalud
RD Apr 7, 2025