RT Journal Article
T1 TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling.
A1 Falcón, Debora
A1 Galeano-Otero, Isabel
A1 Calderón-Sánchez, Eva
A1 Del Toro, Raquel
A1 Martín-Bórnez, Marta
A1 Rosado, Juan A
A1 Hmadcha, Abdelkrim
A1 Smani, Tarik
K1 TRP channels
K1 calcium
K1 cardiac remodeling
K1 conduction disorders
K1 fibrosis
K1 hypertrophy
AB Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart failure. Sustained neurohumoral activation, pressure-overload, or myocardial injury can cause pathologic hypertrophic growth of the heart followed by interstitial fibrosis. The consequent heart's structural and molecular adaptation might elevate the risk of developing heart failure and malignant arrhythmia. Compelling evidences have demonstrated that Ca2+ entry through TRP channels might play pivotal roles in cardiac function and pathology. TRP proteins are classified into six subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystin), which are activated by numerous physical and/or chemical stimuli. TRP channels participate to the handling of the intracellular Ca2+ concentration in cardiac myocytes and are mediators of different cardiovascular alterations. This review provides an overview of the current knowledge of TRP proteins implication in the pathologic process of some frequent cardiac diseases associated with the adverse cardiac remodeling such as cardiac hypertrophy, fibrosis, and conduction alteration.
SN 1664-042X
YR 2019
FD 2019-03-01
LK http://hdl.handle.net/10668/13724
UL http://hdl.handle.net/10668/13724
LA en
DS RISalud
RD Apr 5, 2025