TY - JOUR AU - van Werkhoven, Cornelis H AU - Ducher, Annie AU - Berkell, Matilda AU - Mysara, Mohamed AU - Lammens, Christine AU - Torre-Cisneros, Julian AU - Rodriguez-BaƱo, Jesus AU - Herghea, Delia AU - Cornely, Oliver A AU - Biehl, Lena M AU - Bernard, Louis AU - Dominguez-Luzon, M Angeles AU - Maraki, Sofia AU - Barraud, Olivier AU - Nica, Maria AU - Jazmati, Nathalie AU - Sablier-Gallis, Frederique AU - de Gunzburg, Jean AU - Mentre, France AU - Malhotra-Kumar, Surbhi AU - Bonten, Marc J M AU - Vehreschild, Maria J G T PY - 2021 DO - 10.1038/s41467-021-22269-y UR - http://hdl.handle.net/10668/17578 T2 - Nature communications AB - Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational... LA - en PB - Nature Publishing Group KW - Aged KW - Anti-bacterial agents KW - Biomarkers KW - Carbapenems KW - Cephalosporins KW - Clostridioides difficile KW - Clostridium Infections KW - Drug therapy, combination KW - Female KW - Fluoroquinolones KW - Follow-up studies KW - Gastrointestinal microbiome KW - Hospitalization KW - Humans KW - Incidence KW - Male KW - Middle aged KW - Penicillins KW - Prospective studies TI - Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics. TY - Research article VL - 12 ER -