RT Journal Article
T1 Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section.
A1 Blanco-Rojo, Ruth
A1 Maldonado, Jose
A1 Schaubeck, Monika
A1 Özen, Metehan
A1 Lopez-Huertas, Eduardo
A1 Olivares, Monica
K1 cesarean section
K1 gastrointestinal infections
K1 infant formula
K1 probiotics
K1 respiratory infections
K1 Gastrointestinal Diseases
K1 Probiotics
K1 Immune System
AB Cesarean section (CS) disrupts the natural microbiota colonization process in infants, which might compromise immune system maturation, leading to a higher risk of infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum CECT 5716 on the incidence of gastrointestinal and respiratory infections in the CS infant subgroups (n = 173) of three randomized clinical trials in which this probiotic strain was demonstrated to be safe and effective for preventing infections. Therefore, the data for the CS infants were extracted to obtain the incidence rate ratio (IRR) and 95% CI for gastrointestinal and respiratory infections for each study and were then combined to obtain a pooled IRR and 95% CI using the generic inverse variance method. There was a significant reduction of 73% in the incidence of gastrointestinal infections in CS infants receiving L. fermentum CECT 5716 compared with those receiving the control formula [n = 173, IRR: 0.27 (0.13, 0.53), p = 0.0002]. Regarding respiratory infections, although pooled results showed a reduction of 14% in the probiotic group, the difference was not statistically significant [n = 173, IRR (95% CI): 0.86 (0.67, 1.11), p = 0.25]. In conclusion, the administration of L. fermentum CECT 5716 to CS-born infants protects them from gastrointestinal infections by reducing the risk by up to 73% in this population.
PB Frontiers Research Foundation
SN 2296-2360
YR 2022
FD 2022-07-14
LK http://hdl.handle.net/10668/20693
UL http://hdl.handle.net/10668/20693
LA en
NO Blanco-Rojo R, Maldonado J, Schaubeck M, Özen M, López-Huertas E, Olivares M. Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section. Front Pediatr. 2022 Jul 7;10:906924.
DS RISalud
RD Apr 9, 2025