RT Journal Article
T1 SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns
A1 Redondo, Natalia
A1 Zaldívar-López, Sara
A1 Garrido, Juan J.
A1 Montoya, Maria
K1 SARS-CoV-2
K1 Accessory proteins
K1 COVID-19
K1 Immune response
K1 Coronavirus
K1 Proteínas reguladoras y asccesorias virales
K1 Inmunidad
K1 Evasión inmune
K1 Antivirales
AB There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles during infection are still not completely understood. Here, a review on the current knowledge of SARS-CoV-2 accessory proteins is summarized updating new research that could be critical in understanding SARS-CoV-2 interaction with the host. Some accessory proteins such as ORF3b, ORF6, ORF7a and ORF8 have been shown to be important IFN-I antagonists inducing an impairment in the host immune response. In addition, ORF3a is involved in apoptosis whereas others like ORF9b and ORF9c interact with cellular organelles leading to suppression of the antiviral response in infected cells. However, possible roles of ORF7b and ORF10 are still awaiting to be described. Also, ORF3d has been reassigned. Relevant information on the knowns and the unknowns in these proteins is analyzed, which could be crucial for further understanding of SARS-CoV-2 pathogenesis and to design strategies counteracting their actions evading immune responses in COVID-19.
PB Frontiers
YR 2021
FD 2021-07-07
LK http://hdl.handle.net/10668/4334
UL http://hdl.handle.net/10668/4334
LA en
NO Redondo N, Zaldívar-López S, Garrido JJ, Montoya M. SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns. Front Immunol. 2021 Jul 7;12:708264
DS RISalud
RD Apr 8, 2025