TY - JOUR AU - Olombrada, Miriam AU - Peña, Cohue AU - Rodriguez-Galan, Olga AU - Klingauf-Nerurkar, Purnima AU - Portugal-Calisto, Daniela AU - Oborska-Oplova, Michaela AU - Altvater, Martin AU - Gavilanes, Jose G AU - Martinez-Del-Pozo, Alvaro AU - de-la-Cruz, Jesus AU - Garcia-Ortega, Lucia AU - Panse, Vikram Govind PY - 2020 DO - 10.1093/nar/gkaa315 UR - http://hdl.handle.net/10668/15496 T2 - Nucleic acids research AB - The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether α-sarcin targets the SRL only in... LA - en PB - Oxford University Press KW - Ribotoxins KW - Ribonuclease enzymes KW - Ribosomal subunits KW - Ribosomal RNA structure KW - Protein biosynthesis inhibition KW - Yeast cell death KW - Active Transport, Cell Nucleus KW - Cell Nucleolus KW - Cell Nucleus KW - Endoribonucleases KW - Fungal Proteins KW - Protein Biosynthesis KW - RNA, Ribosomal KW - Ribosome Subunits, Large, Eukaryotic KW - Ricin KW - Saccharomyces cerevisiae TI - The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes. TY - research article VL - 48 ER -