%0 Journal Article
%A Pérez-Gómez, Alberto
%A Gasca-Capote, Carmen
%A Vitallé, Joana
%A Ostos, Francisco J
%A Serna-Gallego, Ana
%A Trujillo-Rodríguez, María
%A Muñoz-Muela, Esperanza
%A Giráldez-Pérez, Teresa
%A Praena-Segovia, Julia
%A Navarro-Amuedo, María D
%A Paniagua-García, María
%A García-Gutiérrez, Manuel
%A Aguilar-Guisado, Manuela
%A Rivas-Jeremías, Inmaculada
%A Jiménez-León, María Reyes
%A Bachiller, Sara
%A Fernández-Villar, Alberto
%A Pérez-González, Alexandre
%A Gutiérrez-Valencia, Alicia
%A Rafii-El-Idrissi Benhnia, Mohammed
%A Weiskopf, Daniela
%A Sette, Alessandro
%A López-Cortés, Luis F
%A Poveda, Eva
%A Ruiz-Mateos, Ezequiel
%A Virgen del Rocío Hospital COVID-19 and COHVID-GS Working Teams
%T Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response.
%D 2022
%U http://hdl.handle.net/10668/21873
%X SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors' samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies.
%K COVID-19
%K IL-2
%K SARS-CoV-2
%K Spike
%K T-cell response
%K endemic coronaviruses
%K nucleocapsid
%K polyfunctionality
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