RT Journal Article
T1 The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus.
A1 Sanabria-de la Torre, Raquel
A1 Garcia-Fontana, Cristina
A1 Gonzalez-Salvatierra, Sheila
A1 Andujar-Vera, Francisco
A1 Martinez-Heredia, Luis
A1 Garcia-Fontana, Beatriz
A1 Muñoz-Torres, Manuel
K1 Wnt pathway
K1 cardiovascular disease
K1 macrovascular disease
K1 microvascular disease
K1 type 2 diabetes mellitus
AB Vascular complications are the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). These vascular abnormalities result in a chronic hyperglycemic state, which influences many signaling molecular pathways that initially lead to increased oxidative stress, increased inflammation, and endothelial dysfunction, leading to both microvascular and macrovascular complications. Endothelial dysfunction represents the initial stage in both types of vascular complications; it represents "mandatory damage" in the development of microvascular complications and only "introductory damage" in the development of macrovascular complications. Increasing scientific evidence has revealed an important role of the Wnt pathway in the pathophysiology of the vascular wall. It is well known that the Wnt pathway is altered in patients with T2DM. This review aims to be an update of the current literature related to the Wnt pathway molecules that are altered in patients with T2DM, which may also be the cause of damage to the vasculature. Both microvascular complications (retinopathy, nephropathy, and neuropathy) and macrovascular complications (coronary artery disease, cerebrovascular disease, and peripheral arterial disease) are analyzed. This review aims to concisely concentrate all the evidence to facilitate the view on the vascular involvement of the Wnt pathway and its components by highlighting the importance of exploring possible therapeutic strategy for patients with T2DM who develop vascular pathologies.
PB MDPI AG
YR 2022
FD 2022-06-21
LK http://hdl.handle.net/10668/21170
UL http://hdl.handle.net/10668/21170
LA en
NO Sanabria-de la Torre R, García-Fontana C, González-Salvatierra S, Andújar-Vera F, Martínez-Heredia L, García-Fontana B, , et al. The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus. Int J Mol Sci. 2022 Jun 23;23(13):6995.
NO This research was funded by Instituto de Salud Carlos III grants (PI18-00803, PI21-01069,and PI18-01235), co-funded by the European Regional Development Fund (FEDER) and by a Junta deAndalucía grant (PI-0268-2019). In addition, R.S.-T. was funded by the University of Granada withco-funding by FEDER, (grant number 8110), and C.G.-F. and S.G.-S. were funded by a postdoctoralfellowship (CD20/00022) and a predoctoral fellowship (FI19/00118), respectively, from the Institutode Salud Carlos III.
DS RISalud
RD Apr 11, 2025