TY  - JOUR
AU  - Galindo-Moreno, Maria
AU  - Giraldez, Servando
AU  - Saez, Carmen
AU  - Japon, Miguel A
AU  - Tortolero, Maria
AU  - Romero, Francisco
PY  - 2017
DO  - 10.1038/s41598-017-10506-8
UR  - http://hdl.handle.net/10668/11545
T2  - Scientific reports
AB  - Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis. Due to its essential role, CDK1...
LA  - en
PB  - Nature Publishing Group
KW  - Autophagy
KW  - Gene Expression Regulation, Neoplastic
KW  - HeLa Cells
KW  - Humans
KW  - Proteasome Endopeptidase Complex
KW  - Protein Stability
KW  - SKP Cullin F-Box Protein Ligases
KW  - Signal Transduction
KW  - CDC2 Protein Kinase
KW  - HEK293 Cells
KW  - Histone Deacetylase 6
KW  - MCF-7 Cells
KW  - Protein Binding
KW  - Proteolysis
KW  - Sequestosome-1 Protein
KW  - Ubiquitination
TI  - Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer.
TY  - research article
VL  - 7
ER  -