RT Journal Article
T1 Pharmacist recommendations for carbapenem de-escalation in urinary tract infection within an antimicrobial stewardship program.
A1 Sadyrbaeva-Dolgova, Svetlana
A1 Aznarte-Padial, Pilar
A1 Jimenez-Morales, Alberto
A1 Exposito-Ruiz, Manuela
A1 Calleja-Hernandez, Miguel Angel
A1 Hidalgo-Tenorio, Carmen
K1 Antimicrobial stewardship programs
K1 Carbapenems
K1 De-escalation
K1 Pharmacist recommendations
K1 Urinary tract infection
AB Carbapenem antibiotics are considered the treatment of choice for serious extended-spectrum beta-lactamase-producing Gram-negative bacteria infections. Our objectives were to analyze the results of carbapenem de-escalation therapy in complicated urinary tract infections (UTIs) attended in a third-level Spanish hospital and to evaluate the impact of pharmacist recommendation in this practice, the outcomes obtained, and associated factors. This prospective observational study of carbapenem prescriptions and de-escalation performance was conducted in a third-level hospital between August 1 2013 and July 31, 2014. Data were gathered on carbapenem treatment duration, de-escalation, length of hospital stay, mortality rate, and associated re-admissions. De-escalation, which was only ordered for patients with positive cultures, was conducted in 49.7% of the 163 patients with complicated UTI. More than half (69.1%) of pharmacist interventions were accepted. De-escalation reduced the median hospital stay by five days (p=0.030). Crude hospital mortality was lower in the de-escalation group (7.4% vs. 29.3%, p Carbapenem de-escalation in accordance with pharmacist recommendation proved to be a safe approach in complicated UTI, reducing the hospital stay of patients without affecting the re-admission rate.
PB Elsevier BV
YR 2019
FD 2019-09-18
LK http://hdl.handle.net/10668/14630
UL http://hdl.handle.net/10668/14630
LA en
NO Sadyrbaeva-Dolgova S, Aznarte-Padial P, Jimenez-Morales A, Expósito-Ruiz M, Calleja-Hernández MÁ, Hidalgo-Tenorio C. Pharmacist recommendations for carbapenem de-escalation in urinary tract infection within an antimicrobial stewardship program. J Infect Public Health. 2020 Apr;13(4):558-563.
DS RISalud
RD Apr 9, 2025