RT Journal Article
T1 Circulating antioxidant defences are decreased in healthy people after a high-fat meal.
A1 Cardona, Fernando
A1 Túnez, Isaac
A1 Tasset, Inmaculada
A1 Garrido-Sánchez, Lourdes
A1 Collantes, Eduardo
A1 Tinahones, Francisco José
K1 Uric acid
K1 Oxidative Stress
K1 Postprandial hyperlipidaemia
K1 High-fat meal
K1 Antioxidantes
K1 HDL-Colesterol
K1 Grasas en la Dieta
K1 Peroxidación de Lípido
K1 Triglicéridos
AB The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
PB Cambridge University Press
SN 0007-1145
YR 2008
FD 2008-08
LK http://hdl.handle.net/10668/1130
UL http://hdl.handle.net/10668/1130
LA en
NO Cardona F, Túnez I, Tasset I, Garrido-Sánchez L, Collantes E, Tinahones FJ. Circulating antioxidant defences are decreased in healthy people after a high-fat meal. Br. J. Nutr. 2008; 100(2):312-6
NO Journal Article; The research group belongs to the ‘Centros de Investigación en Red’ (CIBER, CB06/03/0018) of the Instituto de Salud Carlos III, SAF 2006/12 894 of the MCYT, Madrid, Spain.
DS RISalud
RD Mar 14, 2025