RT Journal Article
T1 Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study.
A1 Lope, Virginia
A1 Martín, Miguel
A1 Castelló, Adela
A1 Ruiz, Amparo
A1 Casas, Ana Mª
A1 Baena-Cañada, José Manuel
A1 Antolín, Silvia
A1 Ramos-Vázquez, Manuel
A1 García-Sáenz, José Ángel
A1 Muñoz, Montserrat
A1 Lluch, Ana
A1 de Juan-Ferré, Ana
A1 Jara, Carlos
A1 Sánchez-Rovira, Pedro
A1 Antón, Antonio
A1 Chacón, José Ignacio
A1 Arcusa, Angels
A1 Jimeno, Mª Angeles
A1 Bezares, Susana
A1 Vioque, Jesús
A1 Carrasco, Eva
A1 Pérez-Gómez, Beatriz
A1 Pollán, Marina
AB This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an offset and physical activity as explanatory. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend 20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend 
YR 2019
FD 2019-03-07
LK http://hdl.handle.net/10668/13675
UL http://hdl.handle.net/10668/13675
LA en
DS RISalud
RD Apr 5, 2025