RT Journal Article
T1 Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder.
A1 Requena-Ocaña, Nerea
A1 Flores-Lopez, Maria
A1 Papaseit, Esther
A1 Garcia-Marchena, Nuria
A1 Ruiz, Juan Jesus
A1 Ortega-Pinazo, Jesus
A1 Serrano, Antonia
A1 Pavon-Moron, Francisco Javier
A1 Farre, Magi
A1 Suarez, Juan
A1 Rodriguez-de-Fonseca, Fernando
A1 Araos, Pedro
K1 VEGFA
K1 Addiction
K1 Alcohol use disorders
K1 Blood–brain barrier
K1 Chemokines
K1 Cognitive dysfunction
K1 Dementia
K1 Fractalkine
K1 Neurodegeneration
K1 Neuroinflammation
AB Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. Alcohol can also disrupt the blood-brain barrier, facilitating the penetration of pro-inflammatory molecules throughout vascular endothelial growth factor A (VEGFA). Thus, alcohol-induced alterations in chemokines and VEGFA might contribute to the neuroinflammation and cognitive impairment associated with AUD. (2) Methods: The present cross-sectional study investigates whether patients with AUD (n = 86) present cognitive disability associated to alterations in plasma concentration of SDF-1, fractalkine, eotaxin, MCP-1, MIP-1α and VEGFA when compared to control subjects (n = 51). (3) Results: The analysis indicated that SDF-1 and MCP-1 concentrations were higher in AUD patients than in controls. Concentrations of VEGFA were higher in AUD patients with severe frontal deficits, and the score of frontal lobe functions was negatively correlated with VEGFA and fractalkine. Acute alcohol effects on VEGFA plasma levels in healthy volunteers demonstrated the induction of VEGFA release by heavy alcohol drinking. VEGFA was positively correlated with pro-inflammatory chemokines in AUD patients with frontal cognitive impairment. (4) Conclusions: we propose VEGFA/chemokine monitoring as biomarkers of potential cognitive impairment in AUD patients.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-04-20
LK http://hdl.handle.net/10668/20826
UL http://hdl.handle.net/10668/20826
LA en
NO Requena-Ocaña N, Flores-Lopez M, Papaseit E, García-Marchena N, Ruiz JJ, Ortega-Pinazo J, et al. Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder. Biomedicines. 2022 Apr 20;10(5):947
NO RETICS Red de Trastornos Adictivos, Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovación and European Regional Development Funds—European Union (ERDF-EU) (RD16/0017/0001 and RD16/0017/003); ISCIII, ERDF-EU (PI20/01399, PI19/01577, PI19/00886); Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas (PND 2020I048, PND 2019I040, PND 2018I044, PND 2018I033, PND 2016I024 and PND 2018I037) and Consejería de Salud y Familia, Junta de Andalucía (Neuro-RECA, RIC-0111-2019). F.J.P.-M. (CPII19/00022) and A.S. (CPII19/00031) hold “Miguel Servet II” research contracts from the National System of Health, ISCIII, ERDF-EU. F.J.P.-M. also holds a “Nicolas Monardes” contract from Servicio Andaluz de Salud, Consejería de Salud y Familia, Junta de Andalucía (C1-0049-2019). P.A. has a research contract (UMA-FEDERJA-076) funded by the Ministry of Economy and Knowledge—Regional Government of Andalucía and ERDF-EU. “PFIS” Predoctoral research contract (FI18/00249) financed by ISCIIIERDF/ESF and NGM has a ‘Sara Borrell’ Research Contract (CD19/00019) financed by ISCIII and ERDF-EU.
DS RISalud
RD Apr 7, 2025