RT Journal Article
T1 Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHREaEuro
A1 Calhaz-Jorge, C.
A1 de Geyter, C.
A1 Kupka, M. S.
A1 de Mouzon, J.
A1 Erb, K.
A1 Mocanu, E.
A1 Motrenko, T.
A1 Scaravelli, G.
A1 Wyns, C.
A1 Goossens, V.
A1 Gliozheni, Orion
A1 Strohmer, Heinz
A1 Petrovskaya, Elena
A1 Tishkevich, Oleg
A1 Wyns, Christine
A1 Bogaerts, Kris
A1 Antonova, Irena
A1 Vrcic, Hrvoje
A1 Ljiljak, Dejan
A1 Rezabek, Karel
A1 Markova, Jitka
A1 Lemmen, Josephine
A1 Erb, Karin
A1 Soritsa, Deniss
A1 Gissler, Mika
A1 Tiitinen, Aila
A1 Royere, Dominique
A1 Tandler-Schneider, Andreas
A1 Uszkoriet, Monika
A1 Loutradis, Dimitris
A1 Tarlatzis, Basil C.
A1 Urbancsek, Janos
A1 Kosztolanyi, G.
A1 Bjorgvinsson, Hilmar
A1 Mocanu, Edgar
A1 Scaravelli, Giulia
A1 Lokshin, Vyacheslav
A1 Ravil, Valiyev
A1 Gudleviciene, Zivile
A1 Lopes, Giedre Belo
A1 Moshin, Veaceslav
A1 Simic, Tatjana Motrenko
A1 Vukicevic, Dragana
A1 Romundstad, Liv Bente
A1 Kurzawa, Rafael
A1 Calhaz-Jorge, Carlos
A1 Laranjeira, Ana Rita
A1 Rugescu, Ioana
A1 Doroftei, Bogdan
A1 Korsak, Vladislav
A1 Radunovic, Nebosja
A1 Tabs, Nada
A1 Tomazevic, Tomaz
A1 Virant-Klun, Irma
A1 Hernandez Hernandez, Juana
A1 Castilla Alcala, Jose Antonio
A1 Bergh, Christina
A1 Weder, Maya
A1 De Geyter, Christian
A1 Smeenk, Jesper M. J.
A1 Gryshchenko, Mykola
A1 Baranowski, Richard
K1 IVF
K1 ICSI
K1 intrauterine insemination
K1 egg donation
K1 frozen embryo replacement
K1 Europe
K1 data collection
K1 registry
K1 Sperm injection
K1 Trends
AB The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years?Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before.Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction.Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information.From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included.In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1% in 2011) and 33.8% (33.2% in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9% in 2011) and 32.3% (31.8% in 2011). In FER cycles, the PR per thawing/warming increased to 23.1% (21.3% in 2011). In ED cycles, the PR per fresh transfer increased to 48.4% (45.8% in 2011) and to 35.9% (33.6% in 2011) per thawed transfer, while it was 45.1% for transfers after FOR. The delivery rate after IUI remained stable, at 8.5% (8.3% in 2011) after IUI-H and 12.0% (12.2% in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1% of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6%, respectively, resulting in a total multiple delivery rate of 17.9% compared with 19.2% in 2011 and 20.6% in 2010. In FER cycles, the multiple delivery rate was 12.5% (12.2% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0%/0.4% and 7.2%/0.5%, following treatment with husband and donor semen, respectively.The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution.The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest.The study has no external funding; all costs are covered by ESHRE. There are no competing interests.
PB Oxford univ press
SN 0268-1161
YR 2016
FD 2016-08-01
LK http://hdl.handle.net/10668/18954
UL http://hdl.handle.net/10668/18954
LA en
NO European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE); Calhaz-Jorge C, de Geyter C, Kupka MS, de Mouzon J, Erb K, et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. Hum Reprod. 2016 Aug;31(8):1638-52.
DS RISalud
RD Apr 7, 2025