RT Journal Article
T1 Healthcare resource utilisation associated with skeletal-related events in European patients with multiple myeloma: Results from a prospective, multinational, observational study.
A1 Ashcroft, John
A1 Duran, Ignacio
A1 Hoefeler, Herbert
A1 Lorusso, Vito
A1 Lueftner, Diana
A1 Campioni, Marco
A1 Intorcia, Michele
A1 Bahl, Amit
K1 advanced cancer
K1 bone lesions
K1 healthcare resource utilisation
K1 multiple myeloma
K1 observational research
K1 skeletal-related events
AB Patients with multiple myeloma (MM) often experience debilitating skeletal-related events (SREs: pathologic fracture, radiation to bone [RB], surgery to bone [SB] or spinal cord compression [SCC]). This is the first comprehensive, prospective, observational analysis of healthcare resource utilisation (HRU), independently attributed to SREs by investigators, in patients with MM. Eligible patients had lytic bone lesions, life expectancy ≥6 months, Eastern Cooperative Oncology Group performance status ≤2 and ≥1 SRE in the 97 days before enrolment. Data were collected retrospectively for 97 days before enrolment and prospectively for 18-21 months. Altogether, 153 patients were enrolled from Germany, Italy, Spain and the United Kingdom. Of the 281 observed SREs, 36.7% required inpatient stays (mean duration: 20.6 days per SRE [standard deviation (SD): 22.9]). SB and SCC were the SREs most likely to require stays (72.3% and 50.0% of SREs, respectively); SCC required the longest mean (SD) stay per event (40.5 [40.8] days). Overall, 179 SREs required outpatient visits; this was most likely for RB (74.8%) and least likely for non-vertebral fracture (50.0%). All SREs were associated with substantial HRU; therefore, preventing SREs in MM will reduce the economic and resource burden on healthcare systems.
YR 2018
FD 2018-03-22
LK http://hdl.handle.net/10668/12139
UL http://hdl.handle.net/10668/12139
LA en
DS RISalud
RD Apr 8, 2025