TY - JOUR AU - Diaz-Gallo, Lina-Marcela AU - Sánchez, Elena AU - Ortego-Centeno, Norberto AU - Sabio, Jose Mario AU - García-Hernández, Francisco J AU - Ramón, Enrique de AU - González-Gay, Miguel A. AU - Witte, Torsten AU - Anders, Hans-Joachim AU - González-Escribano, Maria F AU - Martin, Javier PY - 2013 DO - 10.1371/journal.pone.0060646 UR - http://hdl.handle.net/10668/1421 T2 - PLoS ONE AB - The ubiquitin associated and Src-homology 3 (SH3) domain containing A (UBASH3a) is a suppressor of T-cell receptor signaling, underscoring antigen presentation to T-cells as a critical shared mechanism of diseases pathogenesis. The aim of the present... LA - en PB - Public Library of Science KW - UBASH3A protein, human KW - Adaptor Proteins, Signal Transducing KW - Alelos KW - Predisposición Genética a la Enfermedad KW - Humanos KW - Desequilibrio de Ligamiento KW - Lupus Eritematoso Sistémico KW - Polimorfismo de Nucleótido Simple KW - Sitios de Carácter Cuantitativo KW - Proteínas Adaptadoras Transductoras de Señales KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Linkage KW - Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Lupus Erythematosus, Systemic KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genetic Loci::Quantitative Trait Loci KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Adaptor Proteins, Signal Transducing KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype TI - Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene TY - research article ER -