RT Journal Article
T1 Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition.
A1 Solans, Marta
A1 Benavente, Yolanda
A1 Saez, Marc
A1 Agudo, Antonio
A1 Naudin, Sabine
A1 Hosnijeh, Fatemeh Saberi
A1 Noh, Hwayoung
A1 Freisling, Heinz
A1 Ferrari, Pietro
A1 Besson, Caroline
A1 Mahamat-Saleh, Yahya
A1 Boutron-Ruault, Marie-Christine
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Lasheras, Cristina
A1 Rodríguez-Barranco, Miguel
A1 Amiano, Pilar
A1 Huerta, Jose Maria
A1 Barricarte, Aurelio
A1 Schmidt, Julie A
A1 Vineis, Paolo
A1 Riboli, Elio
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Peppa, Eleni
A1 Masala, Giovanna
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Panico, Salvatore
A1 Skeie, Guri
A1 Weiderpass, Elisabete
A1 Jerkeman, Mats
A1 Ericson, Ulrika
A1 Späth, Florentin
A1 Nilsson, Lena Maria
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Bolvig, Anne Katrine
A1 Tjønneland, Anne
A1 de Sanjose, Silvia
A1 Buckland, Genevieve
A1 Vermeulen, Roel
A1 Nieters, Alexandra
A1 Casabonne, Delphine
K1 Europe
K1 Mediterranean diet
K1 lymphoma
K1 prospective studies
K1 risk
AB There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.
YR 2019
FD 2019-02-05
LK http://hdl.handle.net/10668/13358
UL http://hdl.handle.net/10668/13358
LA en
DS RISalud
RD Apr 14, 2025