RT Journal Article
T1 Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum.
A1 Gutierrez-Cardo, Antonio
A1 Lillo, Eugenia
A1 Murcia-Casas, Belén
A1 Carrillo-Linares, Juan Luis
A1 García-Argüello, Francisco
A1 Sánchez-Sánchez, Purificación
A1 Rodriguez-Morata, Alejandro
A1 Aranda, Isabel Baquero
A1 Sánchez-Chaparro, Miguel Ángel
A1 García-Fernández, María
A1 Valdivielso, Pedro
K1 18F-NaF PET/CT
K1 Phenodex
K1 disease activity
K1 pseudoxanthoma elasticum
AB Pseudoxanthoma elasticum (PXE) is a genetic disease characterized by the calcification of elastin fibers. Our aim was to quantify vascular calcification in the arteries and the deposition of 18F-sodium-fluoride (18F-NaF) in the skin and vessel walls with positron emission tomography/computed tomography. This was an observational study including 18 patients with PXE. Vascular calcification was measured in Agatston units, and deposition in the skin and vessel walls was shown using target-to-background ratio (TBR). Severity of the disease was scored by Phenodex. We found higher vascular calcification in the popliteal, femoral, and aortic arch vessels compared to other vascular regions; however, the uptake of radiotracer was the highest in the aorta and femoral arteries. In the skin, the highest uptake was observed in the neck and the axillae. There was no significant association between 18F-NaF deposition in the arteries or skin and the global Phenodex score. In contrast, the Phenodex score was significantly associated in univariate analyses with the averaged vascular calcium score (p
SN 2077-0383
YR 2020
FD 2020-05-08
LK https://hdl.handle.net/10668/26590
UL https://hdl.handle.net/10668/26590
LA en
DS RISalud
RD Apr 7, 2025