RT Journal Article
T1 Anthropometry and the Risk of Lung Cancer in EPIC.
A1 Dewi, Nikmah Utami
A1 Boshuizen, Hendriek C
A1 Johansson, Mattias
A1 Vineis, Paolo
A1 Kampman, Ellen
A1 Steffen, Annika
A1 Tjønneland, Anne
A1 Halkjær, Jytte
A1 Overvad, Kim
A1 Severi, Gianluca
A1 Fagherazzi, Guy
A1 Boutron-Ruault, Marie-Christine
A1 Kaaks, Rudolf
A1 Li, Kuanrong
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Klinaki, Eleni
A1 Tumino, Rosario
A1 Palli, Domenico
A1 Mattiello, Amalia
A1 Tagliabue, Giovanna
A1 Peeters, Petra H
A1 Vermeulen, Roel
A1 Weiderpass, Elisabete
A1 Torhild Gram, Inger
A1 Huerta, José María
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Ardanaz, Eva
A1 Dorronsoro, Miren
A1 Quirós, José Ramón
A1 Sonestedt, Emily
A1 Johansson, Mikael
A1 Grankvist, Kjell
A1 Key, Tim
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Cross, Amanda J
A1 Norat, Teresa
A1 Riboli, Elio
A1 Fanidi, Anouar
A1 Muller, David
A1 Bueno-de-Mesquita, H Bas
K1 body mass index
K1 lung cancer
K1 obesity
K1 smoking
K1 waist circumference
K1 waist to hip ratio
K1 waist-to-height ratio
AB The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)(2)) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.
YR 2016
FD 2016-07-01
LK http://hdl.handle.net/10668/10234
UL http://hdl.handle.net/10668/10234
LA en
DS RISalud
RD Apr 6, 2025