%0 Journal Article %A Martinez-Trufero, Javier %A De-Sande-Gonzalez, Luis Miguel %A Luna, Pablo %A Martin-Broto, Javier %A Alvarez, Rosa %A Marquina, Gloria %A Diaz-Beveridge, Roberto %A Poveda, Andres %A Cano, Juana Maria %A Cruz-Jurado, Josefina %A Lopez-Pousa, Antonio %A Vaz-Salgado, Maria Angeles %A Valverde-Morales, Claudia M. %A Sevilla, Isabel %A Martinez-Garcia, Jeronimo %A Rubio-Casadevall, Jordi %A De Juan, Ana %A Carrasco, Juan Antonio %A Moura, David S. %A Gurruchaga-Sotes, Ibon %A Gutiérrez, Antonio %T A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study %D 2021 %U http://hdl.handle.net/10668/4498 %X The aim of this study was to identify an easily reliable prognostic score that selects the subset of advanced soft tissue sarcoma (ASTS) patients with a higher benefit with trabectedin in terms of time to progression and overall survival. A retrospective series of 357 patients with ASTS treated with trabectedin as second- or further-line in 19 centers across Spain was analyzed. First, it was confirmed that patients with high growth modulation index (GMI > 1.33) were associated with the better clinical outcome. Univariate and multivariate analyses were performed to identify factors associated with a GMI > 1.33. Thus, GEISTRA score was based on metastasis free-interval (MFI ≤ 9.7 months), Karnofsky < 80%, Non L-sarcomas and better response in the previous systemic line. The median GMI was 0.82 (0–69), with 198 patients (55%) with a GMI < 1, 41 (11.5%) with a GMI 1–1.33 and 118 (33.1%) with a GMI > 1.33. The lowest GEISTRA score showed a median of time-to-progression (TTP) and overall survival (OS) of 5.7 and 19.5 months, respectively, whereas it was 1.8 and 3.1 months for TTP and OS, respectively, for the GEISTRA 4 score. This prognostic tool can contribute to better selecting candidates for trabectedin treatment in ASTS. %K Trabectedin %K Sarcoma %K Growth modulation index %K Prognostic score %K L-sarcoma %K GEISTRA %K Spain %K Advanced soft tissue sarcomas %K Trabectedina %K Pronóstico %K Liposarcoma %K Leiomiosarcoma %K España %~