RT Generic
T1 The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives.
A1 de-Dios-Caballero, Juan
A1 Canton, Rafael
A1 Ponce-Alonso, Manuel
A1 Garcia-Clemente, Marta Maria
A1 Gomez-G-de-la-Pedrosa, Elia
A1 Lopez-Campos, JoseLuis
A1 Maiz, Luis
A1 Del-Campo, Rosa
A1 Martinez-Garcia, Miguel Angel
K1 cross-kingdom interactions
K1 fungal pathogenesis
K1 microbiome
K1 mycobiome
K1 next-generation sequencing
AB Microbes play an important role in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, non-cystic fibrosis bronchiectasis, and asthma. While the role of bacterial pathogens has been extensively studied, the contribution of fungal species to the pathogenesis of chronic lung diseases is much less understood. The recent introduction of next-generation sequencing techniques has revealed the existence of complex microbial lung communities in healthy individuals and patients with chronic respiratory disorders, with fungi being an important part of these communities' structure (mycobiome). There is growing evidence that the components of the lung mycobiome influence the clinical course of chronic respiratory diseases, not only by direct pathogenesis but also by interacting with bacterial species and with the host's physiology. In this article, we review the current knowledge on the role of fungi in chronic respiratory diseases, which was obtained by conventional culture and next-generation sequencing, highlighting the limitations of both techniques and exploring future research areas.
PB MDPI AG
SN 2076-2607
YR 2022
FD 2022-04-13
LK http://hdl.handle.net/10668/21435
UL http://hdl.handle.net/10668/21435
LA en
NO de Dios Caballero J, Cantón R, Ponce-Alonso M, García-Clemente MM, Gómez G de la Pedrosa E, López-Campos JL, et al. The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives. Microorganisms. 2022 Apr 13;10(4):810.
DS RISalud
RD Sep 18, 2025