RT Journal Article
T1 Premature Birth Infants Present Elevated Inflammatory Markers in the Meconium
A1 Rodríguez-Benítez, María Victoria
A1 Gámez-Belmonte, Reyes
A1 Gil-Campos, Mercedes
A1 Hernández-Chirlaque, Cristina
A1 Bouzas, Paula R.
A1 Sánchez de Medina, Fermín
A1 Martínez-Augustin, Olga
K1 Intestinal inflammation
K1 Preterm newborns
K1 Birth weight
K1 Gestational age
K1 Neutrophils
K1 Tracto gastrointestinal
K1 Inflamación
K1 Recien nacido prematuro
K1 Peso al nacer
K1 Edad gestacional
K1 Neutrófilos
AB Introduction: Prematurity, a well-established risk factor for various intestinal diseases in newborns, results in increased morbidity and mortality. However, the intestinal inflammatory status of preterm (PT) infants has been poorly characterized. Here we have broadly described the intestinal and systemic inflammatory status of PT children. Materials and Methods: Meconium and plasma from 39 PT and 32 full term (T) newborns were studied. Fecal calprotectin, polymorphonuclear leukocyte elastase (PMN-E), TNF, IL-17A, IL-8, IP-10, MCP-1, MIP-1, IL-1β, IL-1α, and E-selectin and the enzymatic activities of myeloperoxidase (MPO) and alkaline phosphatase (AP) in meconium were measured. Plasma levels of AP, hepatocyte growth factor, nerve growth factor (NGF), proinflammatory cytokines, leptin, adiponectin, PAI-1, and resistin were also determined. Correlations with gestational age (GA) and birth weight (BW) were studied. Results: Neutrophil derived PMN-E, MPO and calprotectin were increased in the meconium of PT compared to T newborns, while AP was decreased. No significant differences were found in other inflammatory parameters. Considering data from all children, GA and BW showed inverse correlation with neutrophil markers, while AP directly correlated with BW. Plasma levels of IL-1β and NGF were enhanced in PT infants, and were also negatively correlated with BW. PT children additionally showed neutropenia and decreased adiponectin, leptin, haematocrit, and haemoglobin. These parameters (neutrophils, adiponectin, and so forth) were positively correlated with GA and BW, while IL-8, MCP-1, PAI-1, and plasma AP were negatively correlated. PT children showing postnatal morbidity exhibited increased meconium MPO and MIP-1α. Conclusion: PT neonates present a significant elevation of intestinal inflammatory parameters, characterized by the presence of neutrophil markers, associated with mild systemic inflammation.
PB Frontiers
YR 2021
FD 2021-06-18
LK http://hdl.handle.net/10668/4054
UL http://hdl.handle.net/10668/4054
LA en
NO Rodríguez-Benítez MV, Gámez-Belmonte R, Gil-Campos M, Hernández-Chirlaque C, Bouzas PR, Sánchez de Medina F, et al. Premature Birth Infants Present Elevated Inflammatory Markers in the Meconium. Front Pediatr. 2021 Jan 18;8:627475
DS RISalud
RD Apr 19, 2025