RT Journal Article
T1 The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness
A1 Felipe-Abrio, Blanca
A1 Carnero, Amancio
K1 Tumor suppressor
K1 MYBBP1A
K1 MYB
K1 Metabolic plasticity
K1 Stemness
K1 OXPHOS
K1 PGC1-
K1 VHL
K1 Renal cancer
K1 Proteínas supresoras de tumor
K1 Genes myb
K1 Plasticidad de la célula
K1 Metabolismo
K1 Adaptación fisiológica
K1 Fosforilación oxidativa
K1 Coactivador 1-alfa del receptor activado por proliferadores de peroxisomas gamma
K1 Proteína supresora de tumores del síndrome de Von Hippel-Lindau
K1 Neoplasias renales
AB The MYB binding protein 1A (MYBBP1A, also known as p160) acts as a co-repressor of multiple transcription factors involved in many physiological processes. Therefore, MYBBP1A acts as a tumor suppressor in multiple aspects related to cell physiology, most of them very relevant for tumorigenesis. We explored the different roles of MYBBP1A in different aspects of cancer, such as mitosis, cellular senescence, epigenetic regulation, cell cycle, metabolism plasticity and stemness. We especially reviewed the relationships between MYBBP1A, the inhibitory role it plays by binding and inactivating c-MYB and its regulation of PGC-1α, leading to an increase in the stemness and the tumor stem cell population. In addition, MYBBP1A causes the activation of PGC-1α directly and indirectly through c-MYB, inducing the metabolic change from glycolysis to oxidative phosphorylation (OXPHOS). Therefore, the combination of these two effects caused by the decreased expression of MYBBP1A provides a selective advantage to tumor cells. Interestingly, this only occurs in cells lacking pVHL. Finally, the loss of MYBBP1A occurs in 8%-9% of renal tumors. tumors, and this subpopulation could be studied as a possible target of therapies using inhibitors of mitochondrial respiration.
PB MDPI
YR 2020
FD 2020-01-20
LK http://hdl.handle.net/10668/3831
UL http://hdl.handle.net/10668/3831
LA en
NO Felipe-Abrio B, Carnero A. The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness. Cancers. 2020 Jan 20;12(1):254
DS RISalud
RD Apr 11, 2025