RT Journal Article
T1 Genetic Polymorphisms in VEGFR Coding Genes (FLT1/KDR) on Ranibizumab Response in High Myopia and Choroidal Neovascularization Patients.
A1 Blanquez-Martinez, David
A1 Diaz-Villamarin, Xando
A1 Garcia-Rodriguez, Sonia
A1 Antunez-Rodriguez, Alba
A1 Pozo-Agundo, Ana
A1 Martinez-Gonzalez, Luis Javier
A1 Muñoz-Avila, Jose Ignacio
A1 Davila-Fajardo, Cristina Lucia
K1 FLT1
K1 KDR
K1 VEGFR
K1 anti-VEGF
K1 myopia
K1 pharmacogenetics
K1 precision medicine
K1 ranibizumab
AB A severe form of myopia defined as pathologic/high myopia is the main cause of visual impairment and one of the most frequent causes of blindness worldwide. It is characterized by at least 6 diopters or axial length (AL) of eyeball > 26 mm and choroidal neovascularization (CNV) in 5 to 10% of cases. Ranibizumab is a humanized recombinant monoclonal antibody fragment targeted against human vascular endothelial growth factor A (VEGF-A) used in the treatment of CNV. It acts by preventing VEGF-A from interacting with its receptors (VEGFR-1 and -2) encoded by the FLT1 and KDR genes. Several studies found that the KDR and FLT1 genotypes may represent predictive determinants of efficacy in ranibizumab-treated neovascular age-related macular degeneration (nAMD) patients. We performed a retrospective study to evaluate the association of single nucleotide polymorphisms (SNPs) in VEGFR coding genes with the response rate to ranibizumab in patients with high myopia and CNV. In the association study of genotypes in FLT1 with the response to ranibizumab, we found a significant association between two FLT1 variants (rs9582036, rs7993418) with ranibizumab efficacy at the 12-month follow-up. About the KDR gene, we found that two KDR variants (rs2305948, rs2071559) are associated with best-corrected visual acuity (BCVA) improvement and KDR (rs2239702) is associated with lower rates of BCVA worsening considering a 12-month follow-up period.
SN 1999-4923
YR 2022
FD 2022-07-22
LK http://hdl.handle.net/10668/21556
UL http://hdl.handle.net/10668/21556
LA en
NO Blánquez-Martínez D, Díaz-Villamarín X, García-Rodríguez S, Antúnez-Rodríguez A, Pozo-Agundo A, Martínez-González LJ, et al. Genetic Polymorphisms in VEGFR Coding Genes (FLT1/KDR) on Ranibizumab Response in High Myopia and Choroidal Neovascularization Patients. Pharmaceutics. 2022 Jul 26;14(8):1555.
DS RISalud
RD Apr 5, 2025