RT Journal Article
T1 Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study.
A1 Stepien, Magdalena
A1 Duarte-Salles, Talita
A1 Fedirko, Veronika
A1 Floegel, Anne
A1 Barupal, Dinesh Kumar
A1 Rinaldi, Sabina
A1 Achaintre, David
A1 Assi, Nada
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Bastide, Nadia
A1 Boutron-Ruault, Marie-Christine
A1 Severi, Gianluca
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Aleksandrova, Krasimira
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Lagiou, Pagona
A1 Saieva, Calogero
A1 Agnoli, Claudia
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Quirós, J Ramón
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Gavrila, Diana
A1 Barricarte, Aurelio
A1 Ohlsson, Bodil
A1 Sjöberg, Klas
A1 Werner, Mårten
A1 Sund, Malin
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Travis, Ruth C
A1 Schmidt, Julie A
A1 Gunter, Marc
A1 Cross, Amanda
A1 Vineis, Paolo
A1 Romieu, Isabelle
A1 Scalbert, Augustin
A1 Jenab, Mazda
K1 amino acids
K1 biliary tract cancers
K1 hepatocellular carcinoma
K1 prospective cohort
K1 targeted metabolomics
AB Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.
YR 2015
FD 2015-08-21
LK http://hdl.handle.net/10668/10061
UL http://hdl.handle.net/10668/10061
LA en
DS RISalud
RD Apr 18, 2025