RT Journal Article
T1 Fecal microbiota composition is related to brown adipose tissue 18F-fluorodeoxyglucose uptake in young adults.
A1 Ortiz-Alvarez, L
A1 Acosta, F M
A1 Xu, H
A1 Sanchez-Delgado, G
A1 Vilchez-Vargas, R
A1 Link, A
A1 Plaza-Diaz, J
A1 Llamas, J M
A1 Gil, A
A1 Labayen, I
A1 Rensen, P C N
A1 Ruiz, J R
A1 Martinez-Tellez, B
K1 Brown fat
K1 Glucose uptake
K1 Gut microbiota
K1 Obesity
K1 Short-chain fatty acids
AB Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to investigate the association of fecal microbiota composition with BAT volume and activity and mean radiodensity in young adults. 82 young adults (58 women, 21.8 ± 2.2 years old) participated in this cross-sectional study. DNA was extracted from fecal samples and 16S rRNA sequencing was performed to analyse the fecal microbiota composition. BAT was determined via a static 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography scan (PET/CT) after a 2 h personalized cooling protocol. 18F-FDG uptake was also quantified in white adipose tissue (WAT) and skeletal muscles. The relative abundance of Akkermansia, Lachnospiraceae sp. and Ruminococcus genera was negatively correlated with BAT volume, BAT SUVmean and BAT SUVpeak (all rho ≤ - 0.232, P ≤ 0.027), whereas the relative abundance of Bifidobacterium genus was positively correlated with BAT SUVmean and BAT SUVpeak (all rho ≥ 0.262, P ≤ 0.012). On the other hand, the relative abundance of Sutterellaceae and Bifidobacteriaceae families was positively correlated with 18F-FDG uptake by WAT and skeletal muscles (all rho ≥ 0.213, P ≤ 0.042). All the analyses were adjusted for the PET/CT scan date as a proxy of seasonality. Our results suggest that fecal microbiota composition is involved in the regulation of BAT and glucose uptake by other tissues in young adults. Further studies are needed to confirm these findings. ClinicalTrials.gov no. NCT02365129 (registered 18 February 2015).
PB Springer
YR 2022
FD 2022-10-07
LK http://hdl.handle.net/10668/21819
UL http://hdl.handle.net/10668/21819
LA en
NO Ortiz-Alvarez L, Acosta FM, Xu H, Sanchez-Delgado G, Vilchez-Vargas R, Link A, et al. Fecal microbiota composition is related to brown adipose tissue 18F-fluorodeoxyglucose uptake in young adults. J Endocrinol Invest. 2023 Mar;46(3):567-576.
NO Funding for open access charge: Universidad de Granada /CBUA. The study was supported by the Spanish Ministry of Economyand Competitiveness via Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA 12264-I, Retos de laSociedad (DEP2016- 79512-R), and European Regional DevelopmentFunds (ERDF), by the Spanish Ministry of Education (FPU13/04365,FPU16/05159 and FPU17/01523), the Fundación Iberoamericana deNutrición (FINUT), the Redes Temáticas De Investigación CooperativaRETIC (Red SAMID RD16/0022), InFLAMES Flagship Programmeof the Academy of Finland (decision number: 337530), FundaciónAlfonso Martin Escudero and NextGenerationEU (Maria Zambranofellowship: RR_C_2021_04). AstraZeneca HealthCare Foundation,the University of Granada Plan Propio de Investigación 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES),and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF, SOMM17/6107/UGR). AL and RVVare supported by the funds of the European Commission through the“European funds for regional development” (EFRE) as well as by theregional Ministry of Economy, Science and Digitalization of SaxonyAnhalt as part of the “Autonomy in old Age” (AiA) research group for“LiLife” Project (Project ID: ZS/2018/11/95324). We would like tothank the team of the Data Integration Center of University MedicineMagdeburg for local data-analysis solutions; they are supported byMIRACUM and funded by the German Federal Ministry of Education and Research (BMBF) within the “Medical Informatics FundingScheme” (FKZ 01ZZ1801H).
DS RISalud
RD Apr 7, 2025