RT Journal Article
T1 Influence of Diagnostic Delay on Survival Rates for Patients with Colorectal Cancer.
A1 Padilla-Ruiz, Maria
A1 Morales-Suarez-Varela, Maria
A1 Rivas-Ruiz, Francisco
A1 Alcaide, Julia
A1 Varela-Moreno, Esperanza
A1 Zarcos-Pedrinaci, Irene
A1 Tellez, Teresa
A1 Fernandez-de Larrea-Baz, Nerea
A1 Bare, Marisa
A1 Bilbao, Amaia
A1 Sarasqueta, Cristina
A1 Aguirre-Larracoechea, Urko
A1 Quintana, Jose Maria
A1 Redondo, Maximino
K1 Colorectal neoplasms
K1 Delayed diagnosis
K1 Mortality
K1 Prospective cohort study
K1 Survival
AB Colorectal cancer affects men and women alike. Sometimes, due to clinical-pathological factors, the absence of symptoms or the failure to conduct screening tests, its diagnosis may be delayed. However, it has not been conclusively shown that such a delay, especially when attributable to the health system, affects survival. The aim of the present study is to evaluate the overall survival rate of patients with a delayed diagnosis of colorectal cancer. This observational, prospective, multicenter study was conducted at 22 public hospitals located in nine Spanish provinces. For this analysis, 1688 patients with complete information in essential variables were included. The association between diagnostic delay and overall survival at five years, stratified according to tumor location, was estimated by the Kaplan-Meier method. Hazard ratios for this association were estimated using multivariable Cox regression models. The diagnostic delay ≥ 30 days was presented in 944 patients. The presence of a diagnostic delay of more than 30 days was not associated with a worse prognosis, contrary to a delay of less than 30 days (HR: 0.76, 0.64-0.90). In the multivariate analysis, a short delay maintained its predictive value (HR: 0.80, 0.66-0.98) regardless of age, BMI, Charlson index or TNM stage. A diagnostic delay of less than 30 days is an independent factor for short survival in patients with CRC. This association may arise because the clinical management of tumors with severe clinical characteristics and with a poorer prognosis are generally conducted more quickly.
PB MDPI
YR 2022
FD 2022-03-18
LK http://hdl.handle.net/10668/21047
UL http://hdl.handle.net/10668/21047
LA en
NO Padilla-Ruiz M, Morales-Suárez-Varela M, Rivas-Ruiz F, Alcaide J, Varela-Moreno E, Zarcos-Pedrinaci I, et al. Influence of Diagnostic Delay on Survival Rates for Patients with Colorectal Cancer. Int J Environ Res Public Health. 2022 Mar 18;19(6):3626
NO This study was supported by public grants from Instituto de Salud Carlos III (PI09/90397, PS09/00314, PS09/00746, PI09/90453, PI09/00910, PI09/90460, PI09/90490, PI13/01692, PI13/00013, PI18/01181, PI18/01589, PS0900805 & PI0900441) and was co-funded by the European RegionalDevelopment Fund.
DS RISalud
RD Apr 18, 2025