RT Journal Article
T1 Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients.
A1 Almendros, Isaac
A1 Martínez-García, Miguel Ángel
A1 Campos-Rodríguez, Francisco
A1 Riveiro-Falkenbach, Erica
A1 Rodríguez-Peralto, José L
A1 Nagore, Eduardo
A1 Martorell-Calatayud, Antonio
A1 Hernández Blasco, Luis
A1 Bañuls Roca, Jose
A1 Chiner Vives, Eusebi
A1 Sánchez-de-la-Torre, Alicia
A1 Abad-Capa, Jorge
A1 Montserrat, Josep Maria
A1 Pérez-Gil, Amalia
A1 Cabriada-Nuño, Valentín
A1 Cano-Pumarega, Irene
A1 Corral-Peñafiel, Jaime
A1 Diaz-Cambriles, Trinidad
A1 Mediano, Olga
A1 Dalmau-Arias, Joan
A1 Farré, Ramon
A1 Gozal, David
A1 Spanish Sleep Network, 
K1 hypoxia-inducible factor
K1 intermittent hypoxia
K1 melanoma
K1 obstructive sleep apnea
K1 vascular endothelial growth factor
AB Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples. Prospectively recruited patients with CM tumor samples were included and underwent overnight polygraphy. General clinical features, apnea-hypopnea index (AHI), desaturation index (DI4%), and CM characteristics were recorded. Histochemical assessments of VEGF and HIF-1α were performed, and the percentage of positive cells (0, 75%) was blindly tabulated for VEGF expression, and as 0, 0-5.9, 6.0-10.0, >10.0% for HIF-1α expression, respectively. Cases with HIF-1α expression >6% (high expression) were compared with those 10.0% for HIF-1α expression, respectively. Cases with HIF-1α expression >6% (high expression) were compared with those 6% (high expression) were compared with those 75% of cells was compared with those with
SN 1664-2295
YR 2018
FD 2018-04-26
LK http://hdl.handle.net/10668/12458
UL http://hdl.handle.net/10668/12458
LA en
DS RISalud
RD Apr 8, 2025