RT Journal Article
T1 Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial.
A1 Jiménez-Cortegana, Carlos
A1 Sánchez-Martínez, Pilar M
A1 Palazón-Carrión, Natalia
A1 Nogales-Fernández, Esteban
A1 Henao-Carrasco, Fernando
A1 Martín García-Sancho, Alejandro
A1 Rueda, Antonio
A1 Provencio, Mariano
A1 de la Cruz-Merino, Luis
A1 Sánchez-Margalet, Víctor
K1 MDSC
K1 PD-1
K1 Treg
K1 diffuse large B-cell lymphoma
K1 immune system
K1 immunosuppression
K1 lenalidomide
K1 vitamin D
AB The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We have recently found that the level of circulating MDSCs is a good marker of survival in a translational study based on a trial (EudraCT Number: 2014-001620-29), using lenalidomide combined with R-GDP (rituximab plus gemcitabine, cisplatin, and dexamethasone). Since Vitamin D is a known immunomodulator, we have studied blood levels of these cell populations comparing patients with deficit of vitamin D levels (15 ng/mL. Mann-Whitney U test was used to compare cells distributions between groups, Wilcoxon test to compare cells distribution at different times and Spearman test to measure the association between cell populations. Patients with vitamin D deficit maintained the increased level of immune suppressor cells, whereas we observed a depletion of all immune suppressor cells in patients with normal vitamin D levels. In conclusion, we have confirmed the importance of vitamin D in the response to treatment in R/R DLBCL, suggesting that vitamin D deficit may be involved in the immune deficit of these patients, and thus, vitamin D supplementation in these patients may help to obtain a better response, warranting further investigation.
SN 2072-6694
YR 2021
FD 2021-09-15
LK https://hdl.handle.net/10668/27720
UL https://hdl.handle.net/10668/27720
LA en
DS RISalud
RD Feb 23, 2025