RT Journal Article
T1 Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.
A1 Lopez-Mejias, Raquel
A1 Carmona, F David
A1 Genre, Fernanda
A1 Remuzgo-Martinez, Sara
A1 Gonzalez-Juanatey, Carlos
A1 Corrales, Alfonso
A1 Vicente, Esther F
A1 Pulito-Cueto, Veronica
A1 Miranda-Filloy, Jose A
A1 Ramirez-Huaranga, Marco A
A1 Blanco, Ricardo
A1 Robustillo-Villarino, Montserrat
A1 Rodriguez-Carrio, Javier
A1 Alperi-Lopez, Mercedes
A1 Alegre-Sancho, Juan J
A1 Mijares, Veronica
A1 Lera-Gomez, Leticia
A1 Perez-Pampin, Eva
A1 Gonzalez, Antonio
A1 Ortega-Castro, Rafaela
A1 Lopez-Pedrera, Chary
A1 Garcia-Vivar, Mari L
A1 Gomez-Arango, Catalina
A1 Raya, Enrique
A1 Narvaez, Javier
A1 Balsa, Alejandro
A1 Lopez-Longo, Francisco J
A1 Carreira, Patricia
A1 Gonzalez-Alvaro, Isidoro
A1 Rodriguez-Rodriguez, Luis
A1 Fernandez-Gutierrez, Benjamin
A1 Ferraz-Amaro, Iván
A1 Gualillo, Oreste
A1 Castañeda, Santos
A1 Martin, Javier
A1 Llorca, Javier
A1 Gonzalez-Gay, Miguel A
K1 3' Untranslated Regions
K1 Adaptor Proteins, Signal Transducing
K1 Arthritis, Rheumatoid
K1 Atherosclerosis
K1 Carotid Arteries
K1 Carotid Intima-Media Thickness
AB To investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA). We performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analyzed in 2,989 RA patients of European origin. Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals. A genetic variant of the RARB gene (rs116199914) was associated with CIMT values at the genome-wide level of significance (minor allele [G] β coefficient 0.142, P = 1.86 × 10-8 ). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to CV pathophysiology and immune cells. In addition, biologic pathway enrichment and predictive protein-protein relationship analyses, including suggestive GWAS signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence/absence of carotid plaques (Gene Ontology no. 0032964; false discovery rate-adjusted P = 4.01 × 10-3 ). Furthermore, our data suggest potential influences of the previously described candidate CV risk loci NFKB1, MSRA, and ZC3HC1 (P = 8.12 × 10-4 , P = 5.94 × 10-4 , and P = 2.46 × 10-4 , respectively). The present findings strongly suggest that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA.
PB Wiley
YR 2018
FD 2018-01-18
LK http://hdl.handle.net/10668/12993
UL http://hdl.handle.net/10668/12993
LA en
NO López-Mejías R, Carmona FD, Genre F, Remuzgo-Martínez S, González-Juanatey C, Corrales A, et al. Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study. Arthritis Rheumatol. 2019 Mar;71(3):351-360
DS RISalud
RD Sep 16, 2025